IONEBIO iONE rapid test for the detection of neutralizing antibodies COVID19 (SARS-CoV-2)
The prestigious Korean biotechnology laboratory IONEBIO has developed an advanced state-of-the-art immunoassay for the rapid diagnosis of COVID-19 infection.
This rapid test offers optimal levels of sensitivity and has been specially designed to verify the presence of neutralizing antibodies after vaccination.
iONE rapid tests will determine whether antibody protection against SARS-CoV-2 is present and continues after vaccination or infection.
The kit uses the immuno-capture method for the detection of human IgG neutralizing antibodies against SARS-CoV-2 in human whole blood, serum or plasma.
This kit is a quick detection by blocking tool, as it mimics the process of neutralizing the virus. The protein-protein interaction between RBD and ACE2 can be blocked by neutralizing antibodies against SARS-CoV-2 RBD.
The iONE rapid tests are designed for the qualitative in vitro detection of human IgG antibodies against SARS-CoV-2 and neutralizing antibodies that block the interaction. These tests are only provided to healthcare professionals.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense, unsegmented, enveloped RNA virus. This virus is the cause of coronavirus disease 2019 (COVID-19) that is contagious in humans. SARS-CoV-2 has several structural proteins including peak (S), envelope (E), membrane (M), and nucleocapsid (N). The spike protein (S) contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor, the angiotensin-converting enzyme-2 (ACE2).
The CoV-2 S protein interacts strongly with the human ACE2 receptor which leads to endocytosis in the host cells of the pulmonary sac.
SARS-CoV-2 infection initiates an immune response, which includes the production of antibodies in the blood. This production of antibodies provides protection against future virus infections, as they remain in the circulatory system for months after infection and will quickly and strongly bind to the pathogen to block cell infiltration and replication. These antibodies are called neutralizing antibodies.
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